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Article

Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome.

GeroScience - 1 Apr 2024

Hisama Fuki M, Pillai Renuka Kandhaya, Sidorova Julia, Patterson Karynne, Gokingco Carolina, Yacobi-Bach Michal, Oshima Junko

Abstract excerpt

A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting...

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Identifiers

PMID: 37603195
DOI: 10.1007/s11357-023-00907-1
PMCID: PMC10828386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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