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Article

Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice

1 Jan 2021

Abstract excerpt

Abstract Hutchinson–Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells and mouse models, high levels of interleukin‐6, an inflammatory cytokine linked to aging processes, have been detected. Here, we show that inhibition of interleukin‐6 activity by tocilizumab, a neutralizing antibody raised against...

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PMID: 33393189
DOI: 10.1111/acel.13285

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