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Article

Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.

Nature cell biology - 1 Apr 2024

Yang Yuanxin, Zhang Jian, Lv Mingming, Cui Na, Shan Bing, Sun Qi, Yan Lingjie, Zhang Mengmeng, Zou Chengyu, Yuan Junying, Xu Daichao

Abstract excerpt

Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the accumulation of farnesylated prelamin A. Here we report that defective prelamin A processing triggers nuclear RIPK1-dependent signalling that leads to necroptosis and inflammation. We show that accumulated prelamin A recruits RIPK1 to the...

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Source

Identifiers

PMID: 38538837
DOI: 10.1038/s41556-024-01374-2

Genes

RIPK1
ZMPSTE24
MLKL
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.PMID 38538837Read ↗

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in miceSemantic proximity Read ↗

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.Semantic proximity Read ↗

Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.Semantic proximity Read ↗

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.Semantic proximity Read ↗

Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency.Semantic proximity Read ↗

Involvement of prelamin A in laminopathies.Semantic proximity Read ↗

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.Semantic proximity Read ↗

Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24Semantic proximity Read ↗

Lamin A/C, laminopathies and premature ageing.Semantic proximity Read ↗

Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype.Semantic proximity Read ↗

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.Semantic proximity Read ↗

Lamin A involvement in ageing processes.Semantic proximity Read ↗

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