Functional reconstitution of glycinergic synapses incorporating  defined glycine receptor subunit combinations.

doi:10.1016/j.neuropharm.2014.10.026

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Article

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.

Neuropharmacology - 1 Feb 2015

Zhang Yan, Dixon Christine L, Keramidas Angelo, Lynch Joseph W

Abstract excerpt

Glycine receptor (GlyR) chloride channels mediate fast inhibitory neurotransmission in the spinal cord and brainstem. Four GlyR subunits (α1-3, β) have been identified in humans, and their differential anatomical distributions underlie a diversity of synaptic isoforms with unique physiological and pharmacological properties. To improve our understanding of these properties, we induced the formation of recombinant...

Topics

Animals
Cells, Cultured
Embryo, Mammalian
Glycine
Hexachlorocyclohexane
Humans
Inhibitory Postsynaptic Potentials
Insecticides
Mutation
Neurons
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Subunits

Rats

Receptors, Glycine

Spinal Cord

Synapses

Transfection

Source

Open in PubMed

Identifiers

PMID: 25445488
DOI: 10.1016/j.neuropharm.2014.10.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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