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Article

Small Molecule Destabilizer of β-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.

Targeted oncology - 1 Oct 2020

Choi Jung Kyu, Cho Heeyeong, Moon Byoung-San

Abstract excerpt

BACKGROUND: Oncogenic K-Ras mutations in colorectal cancer (CRC) combined with APC mutations worsen CRC prognosis and lower drug effectiveness. Thus, inhibition of both Wnt/β-catenin and Ras-MAPK signaling may be a rational strategy to improve the treatment of this cancer. OBJECTIVE: To identify a novel compound inhibiting both Wnt/β-catenin and Ras-MAPK signaling in CRC. METHODS AND PATIENTS: We developed a...

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PMID: 33026592
DOI: 10.1007/s11523-020-00755-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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