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Article

Predicting the Effect of Single Mutations on Protein Stability and Binding with Respect to Types of Mutations.

International journal of molecular sciences - 28 Jul 2023

Pandey Preeti, Panday Shailesh Kumar, Rimal Prawin, Ancona Nicolas, Alexov Emil

Abstract excerpt

The development of methods and algorithms to predict the effect of mutations on protein stability, protein-protein interaction, and protein-DNA/RNA binding is necessitated by the needs of protein engineering and for understanding the molecular mechanism of disease-causing variants. The vast majority of the leading methods require a database of experimentally measured folding and binding free energy changes for...

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PMID: 37569449
DOI: 10.3390/ijms241512073
PMCID: PMC10418460

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