Article

Predicting the Effect of Mutations on Protein Stability and Binding: Assessment of Leading Algorithms Performance and Databases Content with Respect to Types of Mutations

2023-06-02

Abstract excerpt

Development of methods and algorithms to predict the effect of mutations on protein stability, protein-protein, and protein-DNA/RNA binding is necessitated by the needs of protein engineering and for understanding the molecular mechanism of disease-causing variants. The vast majority of the leading methods are either methods with adjustable parameters or machine learning algorithms, both requiring a database of ex...

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Literature Corpus work: 7c36733f-f777-581b-8c4e-a137d491fa82
DOI: 10.20944/preprints202306.0199.v1

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