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Article

Predicting the stability of mutant proteins by computational approaches: an overview.

Briefings in bioinformatics - 20 May 2021

Marabotti Anna, Scafuri Bernardina, Facchiano Angelo

Abstract excerpt

A very large number of computational methods to predict the change in thermodynamic stability of proteins due to mutations have been developed during the last 30 years, and many different web servers are currently available. Nevertheless, most of them suffer from severe drawbacks that decrease their general reliability and, consequently, their applicability to different goals such as protein engineering or the...

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PMID: 32496523
DOI: 10.1093/bib/bbaa074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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