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Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in <i> Nlrp3 <sup>−/−</sup> </i> mice

2024-01-03

Abstract excerpt

Immune response genes are highly polymorphic in humans and mice, with heterogeneity amongst loci driving strain-specific host defense responses. The inadvertent retention of polymorphic loci can introduce confounding phenotypes, leading to erroneous conclusions, and impeding scientific advancement. In this study, we employ a combination of RNAseq and variant calling analyses and identify a substantial region of 12...

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Literature Corpus work
6b599d30-0558-5da9-b514-1e75f4d8b2ee
DOI
10.1101/2024.01.03.573991
Open publication

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Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in <i> Nlrp3 <sup>−/−</sup> </i> miceDOI 10.1101/2024.01.03.573991
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