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The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF165 and downregulating VEGF165b

26 Jul 2023

Abstract excerpt

VEGF 165 and its isoform VEGF 165b have the same length but opposite functions in cancer. Some studies have indicated the important role of VEGF 165 in osteosarcoma (OS); however, VEGF 165b has not been taken into consideration. This study aims to clarify the roles of the two isoforms in OS and the mechanism controlling their formation from an alternative splicing perspective. By in vivo and in vitro experiments,...

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PMID: 37554848
DOI: 10.1016/j.heliyon.2023.e18706

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