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Article

VEGF165b, an Inhibitory Vascular Endothelial Growth Factor Splice Variant

1 Nov 2004

Abstract excerpt

Growth of new blood vessels (angiogenesis), required for all tumor growth, is stimulated by the expression of vascular endothelial growth factor (VEGF). VEGF is up-regulated in all known solid tumors but also in atherosclerosis, diabetic retinopathy, arthritis, and many other conditions. Conventional VEGF isoforms have been universally described as proangiogenic cytokines. Here, we show that an endogenous splice...

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PMID: 15520188
DOI: 10.1158/0008-5472.can-04-0934

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