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Article

p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis.

International journal of cancer - 1 Sept 2008

Díaz Raquel, Peña Cristina, Silva Javier, Lorenzo Yolanda, García Vanesa, García José M, Sánchez Antonio, Espinosa Pablo, Yuste Rosario, Bonilla Félix, Domínguez Gemma

Abstract excerpt

The secreted mitogen vascular endothelial growth factor, VEGF, plays a pivotal role in angiogenesis. Hypoxia, inactivation of p53 and oncogenic K-Ras induce VEGF expression. Other factors such as p73 may also affect VEGF levels. Curiously, p73 may also regulate angiogenesis by affecting the expression of the pigment epithelium-derived factor, PEDF. Additionally, VEGF might harbor additional functions through the...

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PMID: 18546269
DOI: 10.1002/ijc.23619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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