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Article

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice

18 Mar 2008

Abstract excerpt

Vascular endothelial growth factor-A is widely regarded as the principal stimulator of angiogenesis required for tumour growth. VEGF is generated as multiple isoforms of two families, the pro-angiogenic family generated by proximal splice site selection in the terminal exon, termed VEGFxxx, and the anti-angiogenic family formed by distal splice site selection in the terminal exon, termed VEGFxxxb, where xxx is...

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PMID: 18349828
DOI: 10.1038/sj.bjc.6604309

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