Article
Relationship Between P15 Gene Mutation and Formation and Metastasis of Malignant Osteosarcoma.
Medical science monitor : international medical journal of experimental and clinical research - 27 Feb 2016
Yu ChangShui, Wang WenBo
Abstract excerpt
BACKGROUND As a type of primary malignant bone tumor, osteosarcoma has high incidence and poor prognosis, and is predisposed for pulmonary metastasis. The abnormal expression of P15 gene directly participates in the invasion of various cancers. Therefore, this study investigated the gene mutation of P15 in both primary lesion and pulmonary metastasis lesion of osteosarcoma in a rat model, in an attempt to...
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