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Article

Phylogenetic inference from single-cell RNA-seq data.

Scientific reports - 8 Aug 2023

Liu Xuan, Griffiths Jason I, Bishara Isaac, Liu Jiayi, Bild Andrea H, Chang Jeffrey T

Abstract excerpt

Tumors are comprised of subpopulations of cancer cells that harbor distinct genetic profiles and phenotypes that evolve over time and during treatment. By reconstructing the course of cancer evolution, we can understand the acquisition of the malignant properties that drive tumor progression. Unfortunately, recovering the evolutionary relationships of individual cancer cells linked to their phenotypes remains a...

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PMID: 37553438
DOI: 10.1038/s41598-023-39995-6
PMCID: PMC10409753

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