Article
PTCH/SMO gene mutations in odontogenic keratocysts and drug interventions.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Oct 2023
Wang Shan, Hong Yingying, Qu Jiafei, Zhang Jianyun, Zhang Yuhao, Zhai Jiemei, Li Tiejun
Abstract excerpt
BACKGROUND: Odontogenic keratocysts (OKCs) are odontogenic jaw lesions that cause destruction and dysfunction of the jawbone. OKCs can be sporadic or associated with nevoid basic cell carcinoma syndrome (NBCCS). However, the factors that initiate OKCs and the mechanism of cyst formation remain unclear. Here, we investigated the impact of PTCH1 and SMO mutations on disease progression, as well as the effects of...
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