Article
Whole Exome Sequencing of SMO, BRAF, PTCH1 and GNAS in Odontogenic Diseases.
In vivo (Athens, Greece) - 1 Jan 2000
Shimura Michiko, Nakashiro Koh-Ichi, Sawatani Yuta, Hasegawa Tomonori, Kamimura Ryota, Izumi Sayaka, Komiyama Yuske, Fukumoto Chonji, Yagisawa Shuma, Yaguchi Erika, Hitomi-Koide Masayo, Hyodo Toshiki, Uchida Daisuke, Kawamata Hitoshi
Abstract excerpt
BACKGROUND/AIM: Odontogenic diseases are diagnosed based on clinical course, imaging, and histopathology. However, a definitive diagnosis is not always possible. PATIENTS AND METHODS: We analyzed whole exons of SMO, BRAF, PTCH1 and GNAS using next-generation sequencing (NGS) in 18 patients. RESULTS: Of the 6 patients with ameloblastoma, 2 patients had the same missense mutation in BRAF, and 1 patient with...
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