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Article

Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor.

Oral oncology - 1 May 2010

Peacock Zachary S, Cox Darren, Schmidt Brian L

Abstract excerpt

The human homologue of the Drosophila segment polarity gene PTCH1, a tumor suppressor gene within the Sonic Hedgehog pathway has been implicated as the mutation responsible for nevoid basal cell carcinoma syndrome (NBCCS) as well as many other sporadic neoplasms. The calcifying epithelial odontogenic tumor (CEOT) is a rare and aggressive tumor of the jaws. The objective of this study was to investigate the role...

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Source

Identifiers

PMID: 20371205
DOI: 10.1016/j.oraloncology.2010.02.023

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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