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Article

Inhibition of SHH signaling pathway: molecular treatment strategy of odontogenic keratocyst.

Medical hypotheses - 1 Jan 2006

Zhang Lu, Sun Zhi-Jun, Zhao Yi-Fang, Bian Zhuan, Fan Ming-Wen, Chen Zhi

Abstract excerpt

Odontogenic keratocyst (OKC) is a relatively common cystic lesion occurred in the tooth-bearing areas of the jaws. This entity is thought to arise from the dental lamina or its remnant with significant growth capacity and recurrence potential. The Sonic hedgehog (SHH) signaling pathway plays a critical role in tooth development. Patched (PTCH) combines with Smoothened (SMO) to form a receptor complex for SHH...

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Source

Identifiers

PMID: 16806729
DOI: 10.1016/j.mehy.2006.04.062

Genes

SHH
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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