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Genomic Characterization of Aggressive Breast Cancer in Younger Women.

Annals of surgical oncology - 1 Nov 2023

Franco Idalid, Alshalalfa Mohammed, Hernandez Alexandra, Mahal Brandon A, Nguyen Tiffany, Wang Lora, Punglia Rinaa, Swami Nishwant, Goel Neha

Abstract excerpt

PURPOSE: Although breast cancer (BC) risk increases with age, BC in younger women is more aggressive with higher mortality compared with older women. We characterize the genomic landscape of BCs in younger women. METHODS: Clinicopathologic, molecular, and genomic differences across age groups (< 40 years, 40-60 years, > 60 years) in female BC patients were investigated in two large cohorts [AACR-GENIE8.1...

Topics

Humans
Female
Adult
Breast Neoplasms
Middle Aged
Survival Rate
Biomarkers, Tumor
Prognosis
Mutation
Age Factors
Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomics

Erb-b2 Receptor Tyrosine Kinases

BRCA1 Protein

Tumor Suppressor Protein p53

Aged

Source

Identifiers

PMID: 37550448
DOI: 10.1245/s10434-023-14080-4

Genes

BRCA1
CDK12
ERBB2
TP53
CDH1
KMT2C
PIK3CA
PPM1D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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