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Genomic and clinical features in young women with estrogen receptor-positive, HER2-negative breast cancer

24 Sept 2025

Abstract excerpt

BACKGROUND: Young women (≤40 years at diagnosis) with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) represent a high-risk group with distinct biological features. Conventional biomarkers, such as Ki67 and immunohistochemistry (IHC)-based subtypes, are not validated in this population. This study assessed the prognostic value of clinical and...

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PMID: 40997745
DOI: 10.1016/j.esmoop.2025.105764

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