Article
Prevalence of targetable genomic alterations in young women with advanced breast cancer: a cross-sectional study.
Breast cancer research and treatment - 1 Feb 2024
Blansky Deanna, Ansari Norin, Gao Lucy, Sokol Ethan S, Sivakumar Smruthy, Huang Richard S P, Pelletier Maureen, Levy Mia, Pavlick Dean, Danziger Natalie, Ross Jeffrey S, Lustberg Maryam, Rozenblit Mariya
Abstract excerpt
PURPOSE: Approximately 5% of breast cancers each year are diagnosed in young women < 40 years who tend to have worse clinical outcomes. We compared genomic alterations using comprehensive genomic profiling (CGP) of tumor tissue among very young women (< 30 years) and young women (30-39 years) compared to women ≥ 40 years at diagnosis. METHODS: 2049 advanced breast cancer cases were submitted to Foundation...
Topics
- Humans
- Female
- Aged
- Breast Neoplasms
- Cross-Sectional Studies
- Mutation
- Prevalence
- Genomics
- Biomarkers, Tumor