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Genomic landscape of metastatic breast cancers in young adults: a liquid biopsy analysis of women aged 20-40 years.

Breast (Edinburgh, Scotland) - 1 Feb 2026

Diab Ernest, Roussel-Simonin Cyril, Giugliano Federica, Dixon-Douglas Julia, Spata Alessandra, Pagliuca Martina, Minot Lauriane, Xu-Vuillard Alexandre, Mosele Fernanda, Grinda Thomas, Viansone Alessandro, Bousrih Chayma, Zeghondy Jean, Ben Ahmed Tarek, Nicotra Claudio, Bayle Arnaud, Italiano Antoine, Delaloge Suzette, Pistilli Barbara, André Fabrice, Ribeiro Joana, Rassy Elie

Abstract excerpt

INTRODUCTION: Breast cancer in young adults (YA) aged 20-40 years has distinct clinical and biological traits compared with older patients. This study evaluated the genomic landscape of metastatic breast cancers (MBC) among YA. METHODS: Patients with MBC enrolled in the STING molecular profile platform (NCT04932525) between 2021 and May 2023 were included. Clinical and genomic features were analyzed by age (≤40...

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Class I Phosphatidylinositol 3-Kinases
Estrogen Receptor alpha
Liquid Biopsy
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PTEN Phosphohydrolase

Receptor, Fibroblast Growth Factor, Type 3

Retinoblastoma Binding Proteins

Ubiquitin-Protein Ligases

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Identifiers

PMID: 41512445
DOI: 10.1016/j.breast.2025.104690
PMCID: PMC12818159

Genes

PIK3CA
ESR1
PTEN
RB1
TP53
BRCA1
CCND1
FGFR3
FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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