Article

Integrating multi-tissue expression and splicing data to prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes with therapeutic potential

2024-09-12

Abstract excerpt

Numerous potential susceptibility genes have been identified for colorectal cancer (CRC). However, it remains unclear which genes have a causal role in CRC risk, whether these genes are associated with specific types of CRC, and if they have potential for therapeutic targeting. We performed a multi-tissue transcriptome-wide association study (TWAS) across six relevant normal tissues (n=187-670) and applied a causa...

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Literature Corpus work: 62f7fc25-6d83-5f0f-a8ad-a14e8321003f
DOI: 10.1101/2024.09.10.24313450

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