Article
Reassessing the association of MUC5B with survival in idiopathic pulmonary fibrosis.
Annals of human genetics - 1 Sept 2023
Cai Siyang, Allen Richard J, Wain Louise V, Dudbridge Frank
Abstract excerpt
A variant in the mucin 5B gene (MUC5B) is strongly associated with the risk of idiopathic pulmonary fibrosis. However, the same variant is associated with increased survival time. Previous work suggested that this may be explained by index event bias, with the true effect being to decrease survival. Here, we reassessed this claim using more recent methods and datasets. We found that the statistical assumptions of...
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