Article
Neutrophil extracellular traps facilitate sympathetic hyperactivity by polarizing microglia toward M1 phenotype after traumatic brain injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2023
Qu Xiaolin, Hou Xiaoxiang, Zhu Kaixin, Chen Wen, Chen Kun, Sang Xianzheng, Wang Chenqing, Zhang Yelei, Xu Haoxiang, Wang Junyu, Hou Qibo, Lv Liquan, Hou Lijun, Zhang Danfeng
Abstract excerpt
Traumatic brain injury (TBI), particularly diffuse axonal injury (DAI), often results in sympathetic hyperactivity, which can exacerbate the prognosis of TBI patients. A key component of this process is the role of neutrophils in causing neuroinflammation after TBI by forming neutrophil extracellular traps (NETs), but the connection between NETs and sympathetic excitation following TBI remains unclear. Utilizing...
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