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Article

[Characteristics of PIK3CA gene mutations in Her2-low breast cancer].

Arkhiv patologii - 1 Jan 2023

Pavlenko I A, Povilaitite P E, Makarevich N S, Kaciyaev V Yu, Petrov A V

Abstract excerpt

BACKGROUND: Mutations in the PIK3CA gene, encoding the catalytic subunit of the PI3K class IA p110α, is a common mechanism of activating of PI3K/AKT/mTOR pathway in breast cancer (BC). The detection of these mutations in patients with hormone-positive Her2-negative BC is of important clinical value, since they are the predictor of the sensitivity of the tumor to the PI3K inhibitor - alpelisib. According to the...

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Identifiers

PMID: 37530184
DOI: 10.17116/patol2023850415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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