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Article

The Wild-Type tRNA Adenosine Deaminase Enzyme TadA Is Capable of Sequence-Specific DNA Base Editing.

Chembiochem : a European journal of chemical biology - 15 Aug 2023

Ranzau Brodie L, Rallapalli Kartik L, Evanoff Mallory, Paesani Francesco, Komor Alexis C

Abstract excerpt

Base editors are genome editing tools that enable site-specific base conversions through the chemical modification of nucleobases in DNA. Adenine base editors (ABEs) convert A ⋅ T to G ⋅ C base pairs in DNA by using an adenosine deaminase enzyme to modify target adenosines to inosine intermediates. Due to the lack of a naturally occurring adenosine deaminase that can modify DNA, ABEs were evolved from a...

Topics

Adenosine Deaminase
Gene Editing
RNA, Transfer
DNA
Mutation
CRISPR-Cas Systems

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36947856
DOI: 10.1002/cbic.202200788
PMCID: PMC10514239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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