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Article

The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD).

Cell communication and signaling : CCS - 7 Jun 2018

Du Jiangfeng, Qin Yaping, Wu Yahong, Zhao Wenshan, Zhai Wenjie, Qi Yuanming, Wang Chuchu, Gao Yanfeng

Abstract excerpt

BACKGROUND: Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fraction of cancer patients and the success makes PD-1 as a valuable target in immune checkpoint therapy. For the rational design of PD-1 targeting modulators, the ligand binding mechanism of PD-1...

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Identifiers

PMID: 29879980
DOI: 10.1186/s12964-018-0239-9
PMCID: PMC5992718

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