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Article

In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis.

Scientific reports - 25 Mar 2021

Sadr Ahmad Shahir, Eslahchi Changiz, Ghassempour Alireza, Kiaei Mahmoud

Abstract excerpt

This study aimed to investigate four of the eight PFN-1 mutations that are located near the actin-binding domain and determine the structural changes due to each mutant and unravel how these mutations alter protein structural behavior. Swapaa's command in UCSF chimera for generating mutations, FTMAP were employed and the data was analyzed by RMSD, RMSF graphs, Rg, hydrogen bonding analysis, and RRdisMaps...

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Source

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Identifiers

PMID: 33767237
DOI: 10.1038/s41598-021-86211-4
PMCID: PMC7994392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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