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Article

Computational and experimental studies of the interaction between phospho-peptides and the C-terminal domain of BRCA1.

Journal of computer-aided molecular design - 1 Nov 2011

Anisimov Victor M, Ziemys Arturas, Kizhake Smitha, Yuan Ziyan, Natarajan Amarnath, Cavasotto Claudio N

Abstract excerpt

The C-terminal domain of BRCA1(BRCT) is involved in the DNA repair pathway by recognizing the pSXXF motif in interacting proteins. It has been reported that short peptides containing this motif bind to BRCA1(BRCT) in the micromolar range with high specificity. In this work, the binding of pSXXF peptides has been studied computationally and experimentally in order to characterize their interaction with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22086652
DOI: 10.1007/s10822-011-9484-3
PMCID: PMC3400539

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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