Article
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth.
ACS chemical biology - 16 Aug 2024
Painter Chelsea D, Sankaranarayanan Nehru Viji, Nagarajan Balaji, Mandel Clausen Thomas, West Alan M V, Setiawan Nicollette J, Park Jeeyoung, Porell Ryan N, Bartels Phillip L, Sandoval Daniel R, Vasquez Gabriel J, Chute John P, Godula Kamil, Vander Kooi Craig W, Gordts Philip L S M, Corbett Kevin D, Termini Christina M, Desai Umesh R, Esko Jeffrey D
Abstract excerpt
Neuropilin-1 acts as a coreceptor with vascular endothelial growth factor receptors to facilitate binding of its ligand, vascular endothelial growth factor. Neuropilin-1 also binds to heparan sulfate, but the functional significance of this interaction has not been established. A combinatorial library screening using heparin oligosaccharides followed by molecular dynamics simulations of a heparin...
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