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Article

A Combined Effect of Polygenic Scores and Environmental Factors on Individual Differences in Depression Level.

Genes - 27 Jun 2023

Kazantseva Anastasiya, Davydova Yuliya, Enikeeva Renata, Mustafin Rustam, Malykh Sergey, Lobaskova Marina, Kanapin Alexander, Prokopenko Inga, Khusnutdinova Elza

Abstract excerpt

The risk of depression could be evaluated through its multifactorial nature using the polygenic score (PGS) approach. Assuming a "clinical continuum" hypothesis of mental diseases, a preliminary assessment of individuals with elevated risk for developing depression in a non-clinical group is of high relevance. In turn, epidemiological studies suggest including social/lifestyle factors together with PGS to address...

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Identifiers

PMID: 37510260
DOI: 10.3390/genes14071355
PMCID: PMC10379734

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