Article
Single-nucleotide polymorphisms in ABC drug transporters alter expression and circulating tenofovir in healthy South African women exposed to pre-exposure prophylaxis.
Pharmacogenomics - 1 Jul 2023
Zondo Nomusa M, Sobia Parveen, Sivro Aida, Ngcapu Sinaye, Mansoor Leila E, Mahomed Sharana, Lewis Lara, Ramsuran Veron, Archary Derseree
Abstract excerpt
Aim: We investigated if single-nucleotide polymorphisms (SNPs) in ATP-binding cassette (ABC) drug transporters alter gene expression and tenofovir disposition in South African women taking Truvada® for HIV prevention. Materials & methods: In 393 women, real-time PCR was used to determine the associations between six SNPs in ABC transporter genes, mRNA expression and circulating-tenofovir. Results: Univariable and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.