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Article

Pharmacogenetics-based population pharmacokinetic analysis of tenofovir in Thai HIV-infected patients.

Pharmacogenomics - 1 Nov 2017

Rungtivasuwan Kanokrat, Avihingsanon Anchalee, Thammajaruk Narukjaporn, Mitruk Siwaporn, Burger David M, Ruxrungtham Kiat, Sukasem Chonlaphat, Punyawudho Baralee

Abstract excerpt

AIM: To develop a population pharmacokinetic model and identify sources of variability, genetic and nongenetic factors, of tenofovir. METHODS: The ABCC2 and ABCC4 polymorphisms were genotyped in 342 patients. A nonlinear mixed effects model was used to develop the population pharmacokinetic model and investigate the influence of these polymorphisms and other patient specific covariates on the pharmacokinetics of...

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Identifiers

PMID: 29061086
DOI: 10.2217/pgs-2017-0128

Genes

ABCC4
ABCC2

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