Article
Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients.
The Journal of antimicrobial chemotherapy - 1 Feb 2014
Sarfo Fred S, Zhang Yuan, Egan Deirdre, Tetteh Lambert A, Phillips Richard, Bedu-Addo George, Sarfo Maame Anima, Khoo Saye, Owen Andrew, Chadwick David R
Abstract excerpt
OBJECTIVES: Efavirenz is widely used in first-line antiretroviral therapy in sub-Saharan Africa. However, exposure to efavirenz shows marked interindividual variability that is genetically mediated with potential for important pharmacodynamic consequences. The aims of this study were to assess the frequencies of CYP2B6, CYP2A6, UGT2B7 and CAR single nucleotide polymorphisms (SNPs) and their impact on plasma...
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