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Article

High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients.

Pharmacogenetics and genomics - 1 Aug 2013

Swart Marelize, Skelton Michelle, Ren Yuan, Smith Peter, Takuva Simbabrashe, Dandara Collet

Abstract excerpt

INTRODUCTION: Efavirenz is primarily metabolized by CYP2B6, with a minor contribution from CYP1A2, CYP2A6, CYP3A4 and CYP3A5. Genetic variability in these genes contributes towards differences in plasma efavirenz concentration, which ultimately leads to either development of adverse drug events or emergence of virus resistance. However, the clinical utility or validity of introducing genotype-assisted dosing is...

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PMID: 23778320
DOI: 10.1097/FPC.0b013e328363176f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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