Article
Mitochondrial DNA mutations in Medulloblastoma.
Acta neuropathologica communications - 27 Jul 2023
Funke Viktoria L E, Sandmann Sarah, Melcher Viktoria, Seggewiss Jochen, Horvath Judit, Jäger Natalie, Kool Marcel, Jones David T W, Pfister Stefan M, Milde Till, Rutkowski Stefan, Mynarek Martin, Varghese Julian, Sträter Ronald, Rust Stephan, Seelhöfer Anja, Reunert Janine, Fiedler Barbara, Schüller Ulrich, Marquardt Thorsten, Kerl Kornelius
Abstract excerpt
To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups-WNT, SHH, group 3 (G3) and group 4 (G4). However, there is little information about the relevance of pathogenic mitochondrial DNA (mtDNA) mutations and their consequences across these. In this report, we describe the case of a female...
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