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Article

The mitochondrial genome is a "genetic sanctuary" during the oncogenic process.

PloS one - 1 Jan 2011

Seoane Marcos, Mosquera-Miguel Ana, Gonzalez Teresa, Fraga Maximo, Salas Antonio, Costoya Jose A

Abstract excerpt

Since Otto Warburg linked mitochondrial physiology and oncogenesis in the 1930s, a number of studies have focused on the analysis of the genetic basis for the presence of aerobic glycolysis in cancer cells. However, little or no evidence exists today to indicate that mtDNA mutations are directly responsible for the initiation of tumor onset. Based on a model of gliomagenesis in the mouse, we aimed to explore...

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PMID: 21858071
DOI: 10.1371/journal.pone.0023327
PMCID: PMC3157371

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