Article
Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population.
Molecular genetics & genomic medicine - 1 Dec 2023
Li Xia, Ploner Alexander, Wang Yunzhang, Mak Jonathan K L, Lu Yi, Magnusson Patrik K E, Jylhävä Juulia, Hägg Sara
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) is a sensitive biomarker of inflammation with moderate heritability. The role of rare functional genetic variants in relation to serum CRP is understudied. We aimed to examine gene mutation burden of protein-altering (PA) and loss-of-function (LOF) variants in association with serum CRP, and to further explore the clinical relevance. METHODS: We included 161,430 unrelated...
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