Article
Suggestive genome-wide associations with inflammatory biomarkers in an admixed population, including a missense variant in the OR6K6 olfactory receptor gene associated with MCP-1.
Frontiers in immunology - 1 Jan 2026
Leite Jean Michel R S, Pascoal Gabriela F L, Duarte Graziela B S, Cerqueira Andressa, Fisberg Regina M, Sarti Flavia M, Rogero Marcelo M
Abstract excerpt
Background: Chronic low-grade inflammation drives cardiometabolic diseases and has a strong genetic basis. Most genome-wide association studies (GWAS) have focused on European populations, limiting knowledge of the genetic influences on inflammation in admixed populations such as those in Brazil. Methods: This study is part of the cross-sectional ISA Capital Health Survey. It uses data from the 2015 ISA Nutrition...
Read the complete abstract on PubMedTopics
- Humans
- Male
- Female
- Genome-Wide Association Study
- Chemokine CCL2
- Middle Aged