Article
Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.
Nature genetics - 1 Oct 2018
Maguire Lillias H, Handelman Samuel K, Du Xiaomeng, Chen Yanhua, Pers Tune H, Speliotes Elizabeth K
Abstract excerpt
Diverticular disease is common and has a high morbidity. Treatments are limited owing to the poor understanding of its pathophysiology. Here, to elucidate its etiology, we performed a genome-wide association study of diverticular disease (27,444 cases; 382,284 controls) from the UK Biobank and tested for replication in the Michigan Genomics Initiative (2,572 cases; 28,649 controls). We identified 42 loci...
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