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Article

A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development.

Cell host & microbe - 9 Aug 2023

Sharafutdinov Irshad, Tegtmeyer Nicole, Linz Bodo, Rohde Manfred, Vieth Michael, Tay Alfred Chin-Yen, Lamichhane Binit, Tuan Vo Phuoc, Fauzia Kartika Afrida, Sticht Heinrich, Yamaoka Yoshio, Marshall Barry J, Backert Steffen

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) in various human genes are key factors in carcinogenesis. However, whether SNPs in bacterial pathogens are similarly crucial in cancer development is unknown. Here, we analyzed 1,043 genomes of the stomach pathogen Helicobacter pylori and pinpointed a SNP in the serine protease HtrA (position serine/leucine 171) that significantly correlates with gastric cancer. Our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37490912
DOI: 10.1016/j.chom.2023.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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