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Article

Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori.

Trends in microbiology - 1 Sept 2024

Linz Bodo, Sticht Heinrich, Tegtmeyer Nicole, Backert Steffen

Abstract excerpt

Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen Helicobacter pylori. Those include an alanine-threonine polymorphism in the EPIYA-B phosphorylation motif of the injected effector protein CagA that affects cancer risk by modifying inflammatory responses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38485609
DOI: 10.1016/j.tim.2024.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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