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Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.

Molecular microbiology - 1 Mar 2016

Tegtmeyer Nicole, Moodley Yoshan, Yamaoka Yoshio, Pernitzsch Sandy Ramona, Schmidt Vanessa, Traverso Francisco Rivas, Schmidt Thomas P, Rad Roland, Yeoh Khay Guan, Bow Ho, Torres Javier, Gerhard Markus, Schneider Gisbert, Wessler Silja, Backert Steffen

Abstract excerpt

HtrA proteases and chaperones exhibit important roles in periplasmic protein quality control and stress responses. The genetic inactivation of htrA has been described for many bacterial pathogens. However, in some cases such as the gastric pathogen Helicobacter pylori, HtrA is secreted where it cleaves the tumour-suppressor E-cadherin interfering with gastric disease development, but the generation of htrA...

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PMID: 26568477
DOI: 10.1111/mmi.13276
PMCID: PMC4832355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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