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Article

Host and Helicobacter pylori HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma.

Gut microbes - 31 Dec 2026

Linz Bodo, Rajaratnam Saiswaroop, Tegtmeyer Nicole, Chhetri Aakash, Gunanathan Krishnasalini, Kanchi Subbarao, Pachathundikandi Suneesh Kumar, Sivaramakrishnan Venketesh, Backert Steffen

Abstract excerpt

Helicobacter pylori-associated stomach adenocarcinoma (STAD) represents a highly severe malady, with up to 1 million new cases annually. Here, we examined novel human and bacterial risk determinants as well as related signal transduction events associated with STAD development. H. pylori serine protease HtrA cleaves the junctional protein E-cadherin, which results in the disruption of epithelial cell connections,...

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Share to Antigens, Bacterial
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Temperature Requirement A Serine Peptidase 1

Share to Serine Endopeptidases

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Source

Open in PubMed Open full text

Identifiers

PMID: 42493827
DOI: 10.1080/19490976.2026.2704244
PMCID: PMC13418485

Genes

HTRA1
HTRA2
HTRA3
HTRA4
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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