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Article

Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain.

Medical microbiology and immunology - 1 Jun 2023

Zarzecka Urszula, Tegtmeyer Nicole, Sticht Heinrich, Backert Steffen

Abstract excerpt

The human pathogen Helicobacter pylori is a major risk factor for gastric disease development. Serine protease HtrA is an important bacterial virulence factor that cleaves the cell junction proteins occludin, claudin-8 and E-cadherin, which causes gastric tissue damage. Using casein zymography, we discovered that HtrA trimer stability varies in clinical H. pylori strains. Subsequent sequence analyses revealed...

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Identifiers

PMID: 37183214
DOI: 10.1007/s00430-023-00766-9
PMCID: PMC10293373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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