Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates.

doi:10.1099/mgen.0.000680

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Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates.

Microbial genomics - 1 Nov 2021

Tuan Vo Phuoc, Yahara Koji, Dung Ho Dang Quy, Binh Tran Thanh, Huu Tung Pham, Tri Tran Dinh, Thuan Ngo Phuong Minh, Khien Vu Van, Trang Tran Thi Huyen, Phuc Bui Hoang, Tshibangu-Kabamba Evariste, Matsumoto Takashi, Akada Junko, Suzuki Rumiko, Okimoto Tadayoshi, Kodama Masaaki, Murakami Kazunari, Yano Hirokazu, Fukuyo Masaki, Takahashi Noriko, Kato Mototsugu, Nishiumi Shin, Azuma Takashi, Ogura Yoshitoshi, Hayashi Tetsuya, Toyoda Atsushi, Kobayashi Ichizo, Yamaoka Yoshio

Abstract excerpt

Genome-wide association studies (GWASs) can reveal genetic variations associated with a phenotype in the absence of any hypothesis of candidate genes. The problem of false-positive sites linked with the responsible site might be bypassed in bacteria with a high homologous recombination rate, such as Helicobacter pylori, which causes gastric cancer. We conducted a small-sample GWAS (125 gastric cancer cases and...

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PMID: 34846284
DOI: 10.1099/mgen.0.000680
PMCID: PMC8743543

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