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Impact of Helicobacter pylori Infection and Its Major Virulence Factor CagA on DNA Damage Repair

16 Dec 2020

Abstract excerpt

Helicobacter pylori infection induces a plethora of DNA damages. Gastric epithelial cells, in order to maintain genomic integrity, require an integrous DNA damage repair (DDR) machinery, which, however, is reported to be modulated by the infection. CagA is a major H. pylori virulence factor, associated with increased risk for gastric carcinogenesis. Its pathogenic activity is partly regulated by phosphorylation...

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PMID: 33339161
DOI: 10.3390/microorganisms8122007

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