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N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori

13 Feb 2018

Abstract excerpt

Many bacterial genomes exclusively display an N4-methyl cytosine base (m4C), whose physiological significance is not yet clear. Helicobacter pylori is a carcinogenic bacterium and the leading cause of gastric cancer in humans. Helicobacter pylori strain 26695 harbors a single m4C cytosine methyltransferase, M2.HpyAII which recognizes 5' TCTTC 3' sequence and methylates the first cytosine residue. To understand...

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Share to Gastric Cancer Management and Outcomes
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PMID: 29481677
DOI: 10.1093/nar/gky126

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